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Den aktiva beståndsdelen är aktiverade dendritceller som tas från friska blodgivare. BioStock: Stadiga framsteg för Immunicums ilixadencel under det gångna året mån, dec 23, 2019 08:42 CET Medan två av dessa befinner sig i preklinisk utvärdering är bolagets huvudkandidat, ilixadencel, på god väg genom kliniska studier där den testas som en del i kombinationsbehandling inom ett flertal cancertyper. Om ilixadencel Cellterapiprodukten ilixadencel är en immunaktiverare som är lagringsbar (”off-the-shelf”) och som utvecklats för behandling av solida tumörer. Om ilixadencel Cellterapiprodukten ilixadencel (tidigare kallad INTUVAX®) är en cancerimmunaktiverare som kan lagras "på hylla" ("off-the-shelf") och som utvecklats för behandling av solida tumörer. Den aktiva ingrediensen är aktiverade allogena dendritceller som tas från friska blodgivare.

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The trial evaluated the efficacy and safety of ilixadencel combined with the targeted anticancer drug Sutent (common name: sunitinib, sunitinib; developed by Pfizer) in the first-line treatment of patients with newly diagnosed metastatic renal cell carcinoma (mRCC). The addition of the off-the-shelf cancer immune primer ilixadencel to sunitinib (Sutent) trended toward a benefit in overall survival (OS) compared with sunitinib alone as a first-line treatment for patients with newly diagnosed metastatic renal cell carcinoma (RCC). 2020-02-10 Ilixadencel har genomgående upprätthållit en positiv säkerhets- och tolerabilitetsprofil och visat initiala tecken på effekt, som visats i den randomiserade Fas II-studien MERECA. Ilixadencel är på väg mot klinisk utveckling i sen fas.

Renegerative Medicine Advanced Therapy-beteckning från FDA. Intressant nog tycks behandling med Ilixadencel ganska kraftigt minska risken att dö, men effekten är framförallt synlig efter 20 månader. Uppdatering (2012-02-12): En till sak vi kan göra är att komplettera kalibreringen av modellen med informationen från Fas I/II, där ju uppföljningen sträcker sig över längre tid och inkluderar dödsfall efter mer än 48 månader .

Immunicum AB publ presenterar prekliniska resultat för

1. “We are very excited to have received the RMAT designation for ilixadencel in kidney cancer as it recognizes both the potential of our novel therapeutic 2017-06-23 2021-03-03 Adding the off-the-shelf, cell-based immunotherapy ilixadencel to frontline sunitinib was associated with an overall survival benefit in patients with metastatic renal cell carcinoma. Ilixadencel showed strong clinical activity with a potential overall survival (OS) benefit in patients with newly diagnosed metastatic renal cell carcinoma (RCC), January 26, 2021 - The FDA has granted the cell-based, off-the-shelf immune primer ilixadencel an orphan drug designation for use as a treatment option in patients with soft tissue sarcoma.

Immunicum AB publ erhåller särläkemedelsstatus, ODD, från

18 Aug 2020 Immunicum AB (publ) Announces Update on Survival Data from Phase II MERECA Trial of Ilixadencel in Kidney Cancer. — Median Overall  2020年5月13日 Immunicum AB公司在一份新闻稿中宣布，FDA授予Ilixadencel（伊利沙定）再生 医学先进疗法(RMAT)称号，用于治疗转移性肾细胞癌(RCC)。 22 okt 2018 ST) announced today the presentation of preclinical results that showed anti- tumor synergy between its lead product ilixadencel and a  13 Jun 2020 Ilixadencel (allogeneic inflammatory dendritic cells) is a cell-based immune primer injected intratumorally that previously has been clinically  2020年2月14日 在新闻。 试验结果显示，Ilixadencel可以改善新诊断的转移性肾癌的反应. 点击这里 订阅免疫  The mechanism of action of ilixadencel is to induce recruitment and activation of endogenous immune cells, including NK cells that subsequently promotes cross-   Bolagets huvudkandidat ilixadencel är en off-the-shelf behandling bestående av celler som injiceras i tumören och rekryterar patientens egna  ilixadencel. Immunicum – del av Sveriges långsiktiga satsning på ATMP.

During the trial, 88 patients were randomly assigned in a two-to-one ratio to the Pressmeddelande 27 november 2017 Immunicum tillkännager positiva preliminära resultat från koncepttest på djur med en kombination av ilixadencel och checkpointh 2020-06-16 Ilixadencel. Targeting solid tumors with an off-the-shelf, cell-based immune primer. Immunicum’s clinical program ilixadencel uses dendritic cells sourced from healthy human donors that are specifically activated to produce significant amounts of vigorous immune stimulatory factors. By administration through intratumoral injection, these cells The mechanism of action of ilixadencel is to induce recruitment and activation of endogenous immune cells, including NK cells that subsequently promotes cross-presentation of cell-associated tumor antigens by co-recruited DCs. Keywords: NK cell; cross-presentation; dendritic cell; ilixadencel; intratumoral.
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Its active ingredient is activated allogeneic dendritic cells, derived from healthy The active ingredients of ilixadencel are dendritic cells (DC) derived from healthy blood donors. These cells are specially activated to produce a large number of powerful immune stimulating factors.

— Median Overall  2020年5月13日 Immunicum AB公司在一份新闻稿中宣布，FDA授予Ilixadencel（伊利沙定）再生 医学先进疗法(RMAT)称号，用于治疗转移性肾细胞癌(RCC)。 22 okt 2018 ST) announced today the presentation of preclinical results that showed anti- tumor synergy between its lead product ilixadencel and a  13 Jun 2020 Ilixadencel (allogeneic inflammatory dendritic cells) is a cell-based immune primer injected intratumorally that previously has been clinically  2020年2月14日 在新闻。 试验结果显示，Ilixadencel可以改善新诊断的转移性肾癌的反应.
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Forskningsbolaget Immunicum meddelar att  Immunicum AB (publ) erhåller särläkemedelsstatus, ODD, från FDA för ilixadencel för behandling av mjukdelssarkom, Soft Tissue Sarcoma  Han syftar på den kliniska Fas I/II-studien med Immunicums huvudprodukt ilixadencel. Med utgångspunkt i de positiva resultaten hos den första  Immunicum tillkännager positiva preliminära resultat från koncepttest på djur med en kombination av ilixadencel och checkpointhämmare. Nature-artikeln idag - stöd för ilixadencel : I abstractet förklaras att framgång i behandlingen med checkpointhämmare kräver optimalt primade CD8+ T-celler inn. Intratumoral administration of an immune primer is a therapeutic vaccine strategy aimed to trigger dendritic cell (DC)-mediated cross-presentation of cell-associated tumor antigens to cytotoxic CD8 + T cells without the need for tumor antigen characterization. Ilixadencel Targeting solid tumors with an off-the-shelf, cell-based immune primer Immunicum’s clinical program ilixadencel uses dendritic cells sourced from healthy human donors that are specifically activated to produce significant amounts of vigorous immune stimulatory factors.

IMMUNICUM: PÅGÅENDE STUDIER MED ILIXADENCEL

Ilixadencel is currently moving towards late-stage clinical development. For more information, please contact: Alex Karlsson-Parra, CSO, Immunicum Telephone: +46 8 732 8400 26 Feb 2021 the positive impact on overall survival that ilixadencel may achieve for [patients with kidney cancer],” said Sven Rohmann, MD, PhD. 26 Aug 2020 The active ingredient in ilixadencel is activated allogeneic dendritic cells, which are derived from healthy blood donors. The intratumoral injection  26 Jan 2021 FDA Grants Orphan Drug Designation to Ilixadencel for Soft Tissue Sarcoma January 26, 2021 - The FDA has granted the cell-based, off-the-  7 Feb 2020 The MERECA study evaluated intratumoral ilixadencel administration prior to kidney removal of the primary tumor-affected kidney followed by  569P Intratumoral injection of allogeneic pro-inflammatory dendritic cells ( ilixadencel) in combination with anti-CTLA-4 treatment induce complete tumour  11 Feb 2020 Combining intratumoral injections of ilixadencel with sunitinib improved responses in patients with newly diagnosed synchronous metastatic  We have shown that intratumoral injections of the immune primer ilixadencel (pro -inflammatory allogeneic dendritic cells) are safe in renal-cell carcinoma. Here  FDA has now granted ilixadencel Orphan Drug Designation for its potential use in sarcoma and liver cancer, and Fast Track Designation for GIST. The Phase Ib  18 Feb 2021 “The Orphan Drug Designations awarded by both the EMA and the FDA for ilixadencel in the GIST indication represent an important step  Immunicum's clinical program ilixadencel uses dendritic cells sourced from healthy human donors that are specifically activated to produce significant amounts  9 Sep 2019 A combination therapy of ilixadencel plus sunitinib (Sutent) achieved complete tumor responses in patients with metastatic renal cell carcinoma  27 Jan 2021 The FDA has granted the cell-based, off-the-shelf immune primer ilixadencel an orphan drug designation for use as a treatment option in  Immunicums fas II-studie MERECA, som testar ilixadencel i patienter med njurcancer, befinner sig nu i slutfasen. Igårkom bolaget med en uppdatering från   Patients in the Phase 1b part of the study will be treated with ilixadencel at an increasing dose and frequency, in combination with standard doses and schedules  29 Aug 2019 Immunicum's allogeneic dendritic cell vaccine ilixadencel has failed to better the survival rate Pfizer's Sutent achieved in a phase 2 metastatic  26 Mar 2021 relating to the designation of "Ilixadencel" as an orphan medicinal product under.

08:00 Immunicum AB (publ) erhåller Fast Track Designation från FDA för ilixadencel för behandling av GIST.